Multigram synthesis of a water-soluble porphyrazine and derived seco-porphyrazine labeling agents.
Org Lett
; 9(25): 5291-4, 2007 Dec 06.
Article
in En
| MEDLINE
| ID: mdl-18001047
ABSTRACT
Porphyrazine III has been synthesized on a large scale (18.4 g), with minimal chromatographic purification by employing a novel one-pot, 3-step sequence. Two dinitrile precursors I and II, the latter of which consisted of a mixture of geometric isomers, were transformed, via the corresponding pyrroline diimines, into a mixture of III and the octa-Ar1-porphyrazine. Isolated macrocycle III was subsequently transformed into IV, a water-soluble seco-porphyrazine suitable for the labeling of biological vectors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Water
/
Metalloporphyrins
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2007
Document type:
Article
Affiliation country:
Reino Unido