Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.

Bedard, Patricia W; Clerin, Valerie; Sushkova, Natalia; Tchernychev, Boris; Antrilli, Thomas; Resmini, Christine; Keith, James C; Hennan, James K; Kaila, Neelu; Debernardo, Silvano; Janz, Kristin; Wang, Qin; Crandall, David L; Schaub, Robert G; Shaw, Gray D; Carter, Laura L

Bedard, Patricia W; Clerin, Valerie; Sushkova, Natalia; Tchernychev, Boris; Antrilli, Thomas; Resmini, Christine; Keith, James C; Hennan, James K; Kaila, Neelu; Debernardo, Silvano; Janz, Kristin; Wang, Qin; Crandall, David L; Schaub, Robert G; Shaw, Gray D; Carter, Laura L.

Affiliation

Bedard PW; Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA. pbedard@wyeth.com

J Pharmacol Exp Ther ; 324(2): 497-506, 2008 Feb.

Article in En | MEDLINE | ID: mdl-18024786

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Collection: 01-internacional Database: MEDLINE Main subject: Vasculitis / P-Selectin / Venous Thrombosis / Disease Models, Animal / Hydroxyquinolines Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2008 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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