[Acquired reactive perforating collagenosis associated with diabetes mellitus and renal insufficiency requiring dialysis]. / Erworbene reaktiv perforierende Kollagenose bei Diabetes mellitus und dialysepflichtiger Niereninsuffizienz.
Dtsch Med Wochenschr
; 132(49): 2624-6, 2007 Dec.
Article
in De
| MEDLINE
| ID: mdl-18050026
ABSTRACT
HISTORY A 60-year-old man with diabetes mellitus and chronic renal insufficiency needing hemodialysis was admitted with a 3 months history of multiple hyperkeratotic papules on the trunk and extremities partly ulcerated with a keratotic central plug. INVESTIGATIONS Laboratory tests revealed elevated levels of blood urea nitrogen, creatinine, and HbA (1c). Histopathology showed vertical strands of collagen perforating from the ulcerated lesions. COURSE, DIAGNOSIS AND TREATMENT The biopsy specimen was consistent with acquired reactive perforating collagenosis. The progression was stopped and secondary wound healing was initiated after two weeks of therapy with allopurinol and PUVA. CONCLUSION:
Acquired reactive perforating collagenosis should be considered when ulcera with oystershell-like keratotic plugs are found especially in patients with predisposing diseases like diabetes and renal insufficiency. A good interdisciplinary cooperation between internist and dermatologist is crucial for the early recognition by histopathology and the immediate treatment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Diseases
/
Collagen Diseases
/
Diabetes Mellitus, Type 2
/
Kidney Failure, Chronic
Type of study:
Risk_factors_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
De
Journal:
Dtsch Med Wochenschr
Year:
2007
Document type:
Article