Improved outcome with multimodality therapy in primary cardiac angiosarcoma.

ABSTRACT

BACKGROUND: A 37-year-old man presented with a history of hemoptysis and associated fever, chills, night sweats, and weight loss. The patient had no other pertinent past medical history. INVESTIGATIONS Physical examination, CT scan, transesophageal echocardiogram, electrocardiogram, MRI scan, and immunohistochemical staining of tumor biopsy. DIAGNOSIS Primary cardiac angiosarcoma of the right atrium with systemic metastases to the pericardium, superior vena cava, and lungs. MANAGEMENT Neoadjuvant and adjuvant chemotherapy with doxorubicin and complete surgical resection of the tumor with reconstruction of the right atrium using bovine pericardium.