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In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.
Boiani, Lucía; Davies, Carolina; Arredondo, Carolina; Porcal, Williams; Merlino, Alicia; Gerpe, Alejandra; Boiani, Mariana; Pacheco, José Pedro; Basombrío, Miguel Angel; Cerecetto, Hugo; González, Mercedes.
Affiliation
  • Boiani L; Departamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay.
Eur J Med Chem ; 43(10): 2229-37, 2008 Oct.
Article in En | MEDLINE | ID: mdl-18255195
5-arylethenylbenzofuroxan derivatives with high in vitro anti-Trypanosoma cruzi activity were studied in vivo using acute murine models of Chagas' disease. The selected compounds, as pure isomeric forms, 1, 2, 3 and 4, or as equimolecular mixture of geometric isomers, 1:2, 3:4, 5:6 were studied against different T. cruzi strains. Consequently, Tulahuen 2 strain, Colombiana strain (resistant to Nifurtimox and Benznidazole), and two different wild strains, one isolated from the wild reservoir Didelphis marsupialis and another one from Uruguayan patients, were selected. No relevant signs of in vivo toxicity were observed with the benzofuroxans orally administered. Compound 1 and the mixture of isomers 1:2 were the best for treating infection against the four studied strains.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzoxazoles / Chagas Disease Limits: Animals Language: En Journal: Eur J Med Chem Year: 2008 Document type: Article Affiliation country: Uruguay Country of publication: Francia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzoxazoles / Chagas Disease Limits: Animals Language: En Journal: Eur J Med Chem Year: 2008 Document type: Article Affiliation country: Uruguay Country of publication: Francia