Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines.
Bioorg Med Chem
; 16(7): 3626-31, 2008 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-18295491
ABSTRACT
Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phthalimides
/
Carcinoma
/
Benzothiazoles
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2008
Document type:
Article
Affiliation country:
China