CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.
J Neuroimmunol
; 196(1-2): 139-42, 2008 May 30.
Article
in En
| MEDLINE
| ID: mdl-18378005
ABSTRACT
Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antigens, CD
/
Polymorphism, Single Nucleotide
/
Multiple Sclerosis
Type of study:
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
Oceania
Language:
En
Journal:
J Neuroimmunol
Year:
2008
Document type:
Article
Affiliation country:
Australia