A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes.

Major, Terry C; Olszewski, Bronia; Rosebury, Wendy; Okerberg, Carlin; Carlson, Tage; Ostroski, Robert; Schroeder, Richard; Kowala, Mark C; Leadley, Robert

Major, Terry C; Olszewski, Bronia; Rosebury, Wendy; Okerberg, Carlin; Carlson, Tage; Ostroski, Robert; Schroeder, Richard; Kowala, Mark C; Leadley, Robert.

Affiliation

Major TC; Cardiovascular and Atherosclerosis Biology, Pfizer Global Research & Development, Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, MI 48105, USA. tcmajor@umich.edu

Cardiovasc Drugs Ther ; 22(6): 469-78, 2008 Dec.

Article in En | MEDLINE | ID: mdl-18679781

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Quinolines / Angiotensin-Converting Enzyme Inhibitors / Cardiotonic Agents / Angiotensinogen / Renin / Kidney Diseases Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Language: En Journal: Cardiovasc Drugs Ther Journal subject: ANGIOLOGIA / CARDIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2008 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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