Effect of cyclosporin A and tacrolimus on sister chromatid exchange frequency in renal transplant patients.
Genet Test
; 12(3): 427-30, 2008 Sep.
Article
in En
| MEDLINE
| ID: mdl-18752452
ABSTRACT
Long-term use of Cyclosporin A (CsA) and Tacrolimus is known to yield serious untoward side effects including nephrotoxicity, neurotoxicity, and malignant tumor formation. Sister chromatid exchange (SCE) is used to assess the genotoxic potential of various agents. A total of 37 postrenal transplant patients receiving either CsA (n = 20) or Tacrolimus (n = 17) were included in this study. The genotoxic effects of CsA and Tacrolimus were assessed by determination of SCE frequency. In patients receiving CsA, SCE frequency was increased significantly compared to that in the control group (p = 0.001), whereas Tacrolimus did not yield such a significant change (p = 0.801). SCE frequency was not correlated with drug dosage (p > 0.05). Our results indicate that the use of CsA, but not Tacrolimus 506, is associated with an increased genotoxic effect in postrenal transplant patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sister Chromatid Exchange
/
Kidney Transplantation
/
Tacrolimus
/
Cyclosporine
/
Immunosuppressive Agents
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Genet Test
Journal subject:
GENETICA
Year:
2008
Document type:
Article
Affiliation country:
Turquía