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Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors.
Frohn, Mike; Viswanadhan, Vellarkad; Pickrell, Alexander J; Golden, Jennifer E; Muller, Kristine M; Bürli, Roland W; Biddlecome, Gloria; Yoder, Sean C; Rogers, Norma; Dao, Jennifer H; Hungate, Randall; Allen, Jennifer R.
Affiliation
  • Frohn M; Department of Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. mfrohn@amgen.com
Bioorg Med Chem Lett ; 18(18): 5023-6, 2008 Sep 15.
Article in En | MEDLINE | ID: mdl-18755588
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Benzimidazoles / Procollagen-Proline Dioxygenase / Hypoxia-Inducible Factor 1, alpha Subunit Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Benzimidazoles / Procollagen-Proline Dioxygenase / Hypoxia-Inducible Factor 1, alpha Subunit Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido