A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
Nat Genet
; 40(10): 1204-10, 2008 Oct.
Article
in En
| MEDLINE
| ID: mdl-18758461
ABSTRACT
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Haplotypes
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Genome, Human
/
Chromosome Mapping
/
Chromosomes, Human
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Genetic Predisposition to Disease
/
Genetic Linkage
Type of study:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Nat Genet
Journal subject:
GENETICA MEDICA
Year:
2008
Document type:
Article
Affiliation country:
Reino Unido