Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis.
Clin Exp Allergy
; 38(12): 1875-81, 2008 Dec.
Article
in En
| MEDLINE
| ID: mdl-19037964
ABSTRACT
BACKGROUND:
IL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL-33/IL1RL1 interaction has been suggested to be important in induction of allergic airway inflammation, serum levels of IL-33 and the genetic influences of the polymorphisms of IL-33 in human allergic diseases are unclear.OBJECTIVE:
The aim of this study was to examine whether the serum IL-33 level and polymorphisms in IL-33 are associated with Japanese cedar (JC) pollinosis, the most common form of allergic rhinitis, and a major public health problem, in Japan.METHODS:
We performed linkage disequilibrium (LD) mapping of the gene using the HapMap database, and two selected tag single nucleotide polymorphisms were genotyped. We conducted an association study of IL-33 (JC pollinosis, n=170; normal controls, n=100) and measured the IL-33 levels in sera of the 270 subjects by ELISA.RESULTS:
Serum levels of IL-33 were significantly higher in patients with JC pollinosis (P=0.0018) than in controls. In genetic association analysis, we found a positive association between the polymorphism and JC pollinosis (P=0.048).CONCLUSION:
Our results support a role for IL-33 in the pathogenesis of JC pollinosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pollen
/
Allergens
/
Rhinitis, Allergic, Seasonal
/
Interleukins
/
Cryptomeria
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Exp Allergy
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Japón