Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 53(3): 1238-41, 2009 Mar.
Article
in En
| MEDLINE
| ID: mdl-19104025
ABSTRACT
Tomopenem (formerly CS-023), a novel 1beta-methylcarbapenem, exhibited high affinity for penicillin-binding protein (PBP) 2 in Staphylococcus aureus, PBP 2 in Escherichia coli, and PBPs 2 and 3 in Pseudomonas aeruginosa, which are considered major lethal targets. Morphologically, tomopenem induced spherical forms in E. coli and short filamentation with bulges in P. aeruginosa, which correlated with the drug's PBP profiles. The potential of resistance of these bacteria to tomopenem was comparable to that to imipenem.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Staphylococcus aureus
/
Carbapenems
/
Penicillin-Binding Proteins
/
Escherichia coli
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2009
Document type:
Article
Affiliation country:
Japón