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The effect of the interaction between obesity and drinking on hyperuricemia in Japanese male office workers.
Shiraishi, Hiroshi; Une, Hiroshi.
Affiliation
  • Shiraishi H; Department of Rehabilitation Medicine, Imazu Red Cross Hospital, Nishi-ku, Fukuoka, Japan. siraisi@rpt.sakura.ne.jp
J Epidemiol ; 19(1): 12-6, 2009.
Article in En | MEDLINE | ID: mdl-19164873
BACKGROUND: Obesity and drinking are acknowledged risk factors for hyperuricemia. However, the effect of the interaction between obesity and drinking on hyperuricemia is not well understood. METHODS: The cases comprised 3028 male office workers with hyperuricemia (serum uric acid level >or=7.0 mg/dL); the controls were 5348 men with a serum uric acid level less than 6.0 mg/dL. Logistic regression analysis was used to assess risk factors for hyperuricemia and the interaction between obesity and drinking in hyperuricemia. Participants were divided into 2 groups according to their BMI: individuals with a BMI of 25 or higher were classified as obese and those with a BMI less than 25 were classified as non-obese. In addition, participants were divided into 5 groups based upon their ethanol consumption. The 2 variables were then combined to create 10 groups. RESULTS: With non-obese non-drinkers as the reference category, the odds ratio for hyperuricemia was 1.80 for non-obese drinkers of less than 25 mL/day of ethanol, 2.15 for non-obese drinkers of 25-49 mL/day, 2.60 for non-obese drinkers of 50-74 mL/day, 2.56 for non-obese drinkers of 75+ mL/day, 4.40 for obese non-drinkers, 5.74 for obese drinkers of less than 25 mL/day, 6.57 for obese drinkers of 25-49 mL/day, 5.55 for obese drinkers of 50-74 mL/day, and 7.77 for obese drinkers of 75+ mL/day. The interaction between obesity and drinking in hyperuricemia was statistically significant. CONCLUSION: Our results suggest that although combining the effects of obesity and drinking did not result in a multiplicative increase in the risk for hyperuricemia, the combined risk was greater than the sum of the effects of obesity and drinking.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Alcohol Drinking / Hyperuricemia / Obesity Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Epidemiol Journal subject: EPIDEMIOLOGIA Year: 2009 Document type: Article Affiliation country: Japón Country of publication: Japón

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Alcohol Drinking / Hyperuricemia / Obesity Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Epidemiol Journal subject: EPIDEMIOLOGIA Year: 2009 Document type: Article Affiliation country: Japón Country of publication: Japón