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Effect of liver regeneration on the pharmacokinetics of immunosuppressive drugs.
Lodewijk, L; Mall, A; Spearman, C W; Kahn, D.
Affiliation
  • Lodewijk L; Department of Surgery and Medical Research Council Liver Research Centre, University of Cape Town, Cape Town, South Africa.
Transplant Proc ; 41(1): 379-81, 2009.
Article in En | MEDLINE | ID: mdl-19249561
ABSTRACT
In liver transplantation the graft has been known to undergo regeneration, which is associated with down-regulation of the cytochrome P450 system. The latter is involved in the metabolism of several immunosuppressive drugs. The aim of this study was to investigate the effect of liver regeneration on the pharmacokinetics (PK) of cyclosporine, rapamycin, and tacrolimus. Rats were subjected to either partial hepatectomy (PH) or sham operation (SH). Cyclosporine, rapamycin, and tacrolimus PK studies were performed at 0, 24, and 96 hours postoperatively. The areas under the curve (AUC), trough levels, and maximum concentrations (Cmax) for cyclosporine and tacrolimus were numerically higher in the animals subjected to PH. The PK studies of rapamycin were not affected by PH. These studies indicated that cyclosporine and tacrolimus metabolism may be inhibited during liver regeneration.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatectomy / Immunosuppressive Agents / Liver Regeneration Type of study: Prognostic_studies Limits: Animals Language: En Journal: Transplant Proc Year: 2009 Document type: Article Affiliation country: Sudáfrica Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatectomy / Immunosuppressive Agents / Liver Regeneration Type of study: Prognostic_studies Limits: Animals Language: En Journal: Transplant Proc Year: 2009 Document type: Article Affiliation country: Sudáfrica Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA