Effect of liver regeneration on the pharmacokinetics of immunosuppressive drugs.
Transplant Proc
; 41(1): 379-81, 2009.
Article
in En
| MEDLINE
| ID: mdl-19249561
ABSTRACT
In liver transplantation the graft has been known to undergo regeneration, which is associated with down-regulation of the cytochrome P450 system. The latter is involved in the metabolism of several immunosuppressive drugs. The aim of this study was to investigate the effect of liver regeneration on the pharmacokinetics (PK) of cyclosporine, rapamycin, and tacrolimus. Rats were subjected to either partial hepatectomy (PH) or sham operation (SH). Cyclosporine, rapamycin, and tacrolimus PK studies were performed at 0, 24, and 96 hours postoperatively. The areas under the curve (AUC), trough levels, and maximum concentrations (Cmax) for cyclosporine and tacrolimus were numerically higher in the animals subjected to PH. The PK studies of rapamycin were not affected by PH. These studies indicated that cyclosporine and tacrolimus metabolism may be inhibited during liver regeneration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatectomy
/
Immunosuppressive Agents
/
Liver Regeneration
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Transplant Proc
Year:
2009
Document type:
Article
Affiliation country:
Sudáfrica
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA