The effects of phototherapy on the numbers of circulating natural killer cells and T lymphocytes in psoriasis.
Photodermatol Photoimmunol Photomed
; 25(2): 109-10, 2009 Apr.
Article
in En
| MEDLINE
| ID: mdl-19292789
The innate immune system is believed to be important in the pathogenesis of psoriasis and natural killer (NK) have been found in increased numbers in psoriatic plaques. Alterations in the numbers of NK cells in peripheral blood have been reported. We investigated the effect of phototherapy on levels of peripheral NK cells and lymphocytes in patients with psoriasis. In nine patients whom we followed before, during and after narrowband ultraviolet B (UVB) treatment there were no differences in the numbers of circulating lymphocytes, lymphocyte subsets or cells expressing NK markers and controls. Treatment with narrowband UVB did, however, significantly lower circulating CD4 counts which gradually recovered posttreatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phototherapy
/
Psoriasis
/
Killer Cells, Natural
/
T-Lymphocytes
/
Cell Movement
Limits:
Adult
/
Humans
Language:
En
Journal:
Photodermatol Photoimmunol Photomed
Journal subject:
ALERGIA E IMUNOLOGIA
/
DERMATOLOGIA
Year:
2009
Document type:
Article
Affiliation country:
Irlanda
Country of publication:
Reino Unido