Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).

Christopher, John A; Bamborough, Paul; Alder, Catherine; Campbell, Amanda; Cutler, Geoffrey J; Down, Kenneth; Hamadi, Ahmed M; Jolly, Adrian M; Kerns, Jeffrey K; Lucas, Fiona S; Mellor, Geoffrey W; Miller, David D; Morse, Mary A; Pancholi, Kiritkant D; Rumsey, William; Solanke, Yemisi E; Williamson, Rick

Christopher, John A; Bamborough, Paul; Alder, Catherine; Campbell, Amanda; Cutler, Geoffrey J; Down, Kenneth; Hamadi, Ahmed M; Jolly, Adrian M; Kerns, Jeffrey K; Lucas, Fiona S; Mellor, Geoffrey W; Miller, David D; Morse, Mary A; Pancholi, Kiritkant D; Rumsey, William; Solanke, Yemisi E; Williamson, Rick.

Affiliation

Christopher JA; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK. john@christopher257.fsnet.co.uk

J Med Chem ; 52(9): 3098-102, 2009 May 14.

Article in En | MEDLINE | ID: mdl-19348415

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors / I-kappa B Kinase / Drug Discovery / Isoquinolines Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2009 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos

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