[Pathogenesis and treatment of vascular calcification in CKD]. / Invecchiamento cardiovascolare nel soggetto uremico: nuove acquisizioni.
G Ital Nefrol
; 26 Suppl 45: S20-7, 2009.
Article
in It
| MEDLINE
| ID: mdl-19382090
ABSTRACT
Increased vascular calcification is a major cause of cardiovascular events in patients with chronic kidney disease (CKD). It is the result of an active ossification process counteracted by ''bone'' proteins such as osteopontin, alkaline phosphatase, osteoprotegerin, and osteocalcin. Chronic kidney disease - mineral and bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism that occurs in CKD. In addition to abnormalities in the serum calcium and phosphate profile, CKD-MBD is characterized by abnormalities of bone turnover, mineralization, volume and growth as well as vascular calcification. Considering that the presence and extent of vascular calcification in CKD portend a poor prognosis, many efforts have been made to shed light on this complicated phenomenon to prevent vascular calcium deposition and its progression. Indeed, careful control of calcium load, serum phosphate and parathyroid hormone along with the use of calcium-free phosphate binders and vitamin D receptor activators represent a new therapeutic armamentarium to improve quality of life and reduce mortality in CKD.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vascular Diseases
/
Calcinosis
/
Kidney Diseases
Type of study:
Etiology_studies
/
Guideline
/
Prognostic_studies
Aspects:
Patient_preference
Limits:
Humans
Language:
It
Journal:
G Ital Nefrol
Journal subject:
NEFROLOGIA
Year:
2009
Document type:
Article
Affiliation country:
Italia