[Screening and preliminary analysis of the apoptosis- and proliferation-related genes in nasopharyngeal carcinoma].
Nan Fang Yi Ke Da Xue Xue Bao
; 29(4): 645-7, 2009 Apr.
Article
in Zh
| MEDLINE
| ID: mdl-19403385
ABSTRACT
UNLABELLED To screen and analyze the apoptosis- and proliferation-related genes in human nasopharyngeal carcinoma (NPC). METHODS:
According to gene ontology classification, the abnormal expressions of the genes related to cell apoptosis and proliferation were identified in the NPC gene chip data. The cell apoptosis- and proliferation-related genes expressed in each of the 3 stages, as defined by the tree model for the pathogenesis and progression of NPC, were screened, and with literature review, their distribution in the tree model were analyzed.RESULTS:
Nineteen genes related to cell apoptosis were found in NPC, among which 9 were down-regulated (such as DNASE1L3) and located in the chromosome deletion regions, and 10 were up-regulated (such as DEDD) in the chromosome amplification regions. Twenty-one cell proliferation-related genes were identified, including 8 down-regulated genes (such as TUSC2) in the chromosome deletion regions and 13 up-regulated ones (such as EMP1) in the chromosome amplification regions. In the chromosome deletion regions, the down-regulated cell apoptosis-related genes participated mostly in inducing and regulating cell apoptosis, and the up-regulated cell proliferation-related genes in the chromosome amplification regions were mostly associated with the positive regulation of cell proliferation.CONCLUSION:
NPC occurs possibly through two pathways by inhibiting cell apoptosis or by promoting excessive cell proliferation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nasopharyngeal Neoplasms
/
Apoptosis
Type of study:
Diagnostic_studies
/
Screening_studies
/
Systematic_reviews
Limits:
Humans
Language:
Zh
Journal:
Nan Fang Yi Ke Da Xue Xue Bao
Year:
2009
Document type:
Article
Affiliation country:
China