Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations.
Cytokine Growth Factor Rev
; 20(3): 213-22, 2009 Jun.
Article
in En
| MEDLINE
| ID: mdl-19493693
ABSTRACT
The bone morphogenetic proteins (BMPs) are cytokines of the transforming growth factor beta family. Some BMPs such as BMP-2 and BMP-7 play a major role in the development of the skeleton and the maintenance of homeostasis during bone remodelling. To date, only BMP-2 and BMP-7 have been approved by the Food and Drug Administration for specific orthopaedic applications. However, due to BMP cost, peptides derived from their knuckle epitope with osteogenic properties have been developed. BMPs are involved in many other biological events, including embryogenesis, angiogenesis and cancer. BMPs therefore have great biomedical potential as osteogenic factors and as anti-cancer agents. This review focuses on the use of BMPs and their derived peptides in biomedical delivery systems and gene therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoblasts
/
Peptides
/
Cell Differentiation
/
Bone Morphogenetic Proteins
/
Mesenchymal Stem Cells
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Cytokine Growth Factor Rev
Journal subject:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Year:
2009
Document type:
Article
Affiliation country:
Canadá