Molecular epidemiology of syphilis in Scotland.
Sex Transm Infect
; 85(6): 447-51, 2009 Oct.
Article
in En
| MEDLINE
| ID: mdl-19497918
ABSTRACT
OBJECTIVE:
To examine the molecular epidemiology of syphilis in Scotland.METHODS:
Ulcer specimens were collected from 85 patients with infectious syphilis. Typing of Treponema pallidum was performed using a method that examines variation in two loci; the number of 60-basepair repeats within the arp gene and sequence variation in the tpr genes.RESULTS:
Patients were predominately white men who have sex with men (MSM). Treponemal DNA was detected in 75 specimens and a total of six subtypes were identified from 58 typeable specimens (77%). The most common subtypes were 14d (44/58, 76%), followed by 14e (7/58, 12%), 14j (3/58, 5%), 14b (2/58, 3%), 14p and 14k (1/58, 2%).CONCLUSIONS:
This study shows that subtype 14d is the predominant subtype circulating in Scotland and there is a surprising level of genetic diversity within the Scottish MSM community.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Treponema pallidum
/
Syphilis
Type of study:
Clinical_trials
/
Screening_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Sex Transm Infect
Journal subject:
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Year:
2009
Document type:
Article
Affiliation country:
Reino Unido