Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review.
J Cutan Pathol
; 36(6): 660-7, 2009 Jun.
Article
in En
| MEDLINE
| ID: mdl-19515045
ABSTRACT
BACKGROUND:
Neonatal lupus erythematosus (NLE) is a disease associated with the transplacental transfer of maternal anti-Ro/SSA. The histopathologic characteristics of neonatal lupus have been described as compatible with cutaneous lupus based on isolated cases.METHODS:
We retrospectively review the available literature and compare them with findings obtained in seven biopsies of five cases.RESULTS:
Erythematous-desquamative lesions and urticaria-like lesions were observed in our series. Two cases showed both type of lesions. Vacuolar alterations at the dermoepidermal interface and adnexal structures were the histopathologic findings on erythematous-desquamative lesions, and a superficial and deep perivascular and periadnexal lymphocytic infiltrate was the major pattern in urticaria-like lesions. One case showed prevalence of eosinophils in the inflammatory infiltrate. Sixty cases have been reported previously. Sixty-five percent presented erythematous-desquamative and 29% urticaria-like lesions. Pathologic findings of erythematous-desquamative lesions were similar to those found in our series, but epidermal vacuolar changes were the predominant histopathologic finding in urticaria-like lesions of cases reported in the literature.CONCLUSIONS:
The majority of cases of NLE show vacuolar alteration at the dermoepidermal interface and adnexal structures. Some cases exhibit a superficial and deep perivascular and periadnexal lymphocytic infiltrate without epidermal alteration, and rare cases may have eosinophils in the infiltrate.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lupus Erythematosus, Cutaneous
Type of study:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Journal:
J Cutan Pathol
Year:
2009
Document type:
Article
Affiliation country:
España