Macrolide-induced digoxin toxicity: a population-based study.
Clin Pharmacol Ther
; 86(4): 383-6, 2009 Oct.
Article
in En
| MEDLINE
| ID: mdl-19606089
ABSTRACT
In this 15-year, population-based, nested case-control study, we investigated the association between hospitalization for digoxin toxicity and recent exposure to individual macrolide antibiotics. Clarithromycin was associated with the highest risk of digoxin toxicity (adjusted odds ratio (OR) 14.8; 95% confidence interval (CI) 7.9-27.9), whereas erythromycin and azithromycin were associated with much lower risk (adjusted OR 3.7; 95% CI 1.7-7.9; and adjusted OR 3.7; 95% CI 1.1-12.5, respectively). We found no increased risk with a neutral comparator, cefuroxime (adjusted OR 0.8; 95% CI 0.2-3.4).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiotonic Agents
/
Macrolides
/
Digoxin
/
Anti-Bacterial Agents
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Pharmacol Ther
Year:
2009
Document type:
Article
Affiliation country:
Canadá