Disseminated bacille Calmette-Guérin disease in HIV-infected South African infants.
Bull World Health Organ
; 87(7): 505-11, 2009 Jul.
Article
in En
| MEDLINE
| ID: mdl-19649364
ABSTRACT
OBJECTIVE:
To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (agedMETHODS:
The numerator, or number of new cases of disseminated BCG disease, was derived from multicentre surveillance data collected prospectively on infants with a confirmed HIV infection during 2004-2006. The denominator, or total number of HIV-infected infants who were BCG-vaccinated, was derived from population-based estimates of the number of live infants and from reported maternal HIV infection prevalence, vertical HIV transmission rates and BCG vaccination rates.FINDINGS:
The estimated incidences of disseminated BCG disease per 100 000 BCG-vaccinated, HIV-infected infants were as follows 778 (95% confidence interval, CI 361-1319) in 2004 (vertical HIV transmission rate 10.4%); 1300 (95% CI 587-2290) in 2005 (transmission rate 6.1%); and 1013 (95% CI 377-1895) in 2006 (transmission rate 5.4%). The pooled incidence over the study period was 992 (95% CI 567-1495) per 100 000.CONCLUSION:
Multicentre surveillance data showed that the risk of disseminated BCG disease in HIV-infected infants is considerably higher than previously estimated, although likely to be under-estimated. There is an urgent need for data on the risk-benefit ratio of BCG vaccination in HIV-infected infants to inform decision-making in settings where HIV infection and tuberculosis burdens are high. Safe and effective tuberculosis prevention strategies are needed for HIV-infected infants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis, Bovine
/
HIV Seropositivity
Type of study:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Animals
/
Humans
/
Infant
Country/Region as subject:
Africa
Language:
En
Journal:
Bull World Health Organ
Year:
2009
Document type:
Article
Affiliation country:
Sudáfrica