Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers.
Aliment Pharmacol Ther
; 30(9): 930-6, 2009 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-19678812
ABSTRACT
BACKGROUND:
The mechanism of action of bisacodyl in the unprepared human colon remains unclear.AIM:
To evaluate the effect of oral bisacodyl on the overall and regional colonic transit in humans.METHODS:
In a double-blind, randomized, placebo-controlled study of 25 healthy participants, effects of oral bisacodyl (5 mg p.o. per day) and placebo on colonic transit were compared. A validated scintigraphy method was used to measure colonic transit. The primary transit endpoints, ascending colon emptying t(1/2) and geometric centre of colon isotope at 24 h (overall transit), were compared (Wilcoxon rank sum test).RESULTS:
There were significant treatment effects on ascending colon t(1/2), with the bisacodyl group demonstrating accelerated emptying [median 6.5 h, interquartile range 5.0-8.0 h] relative to the placebo group [11.0 h (7.0-17.1); P = 0.03]. Numerical differences in colonic geometric centre 24 h [bisacodyl median 3.0 (2.2-3.8), placebo 4.0 (3.1-4.6)] were not significant (P = 0.19). There were no significant differences observed in geometric centre 4 h.CONCLUSION:
Oral 5 mg bisacodyl accelerates ascending colon in the unprepared colon in healthy adults; this action may contribute to the drug's efficacy in constipation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bisacodyl
/
Gastrointestinal Transit
/
Cathartics
/
Colon, Ascending
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Aliment Pharmacol Ther
Journal subject:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2009
Document type:
Article
Affiliation country:
Estados Unidos