Physical activity and physiological cardiac remodelling in a community setting: the Multi-Ethnic Study of Atherosclerosis (MESA).
Heart
; 96(1): 42-8, 2010 Jan.
Article
in En
| MEDLINE
| ID: mdl-19858139
ABSTRACT
OBJECTIVE:
To evaluate the association of physical activity with left ventricular structure and function in the general population in a community setting.DESIGN:
Cross-sectional study.SETTING:
The Multi-Ethnic Study of Atherosclerosis (MESA), a population-based study of subclinical atherosclerosis.PARTICIPANTS:
A multiethnic sample of 4992 participants (aged 45-84 years; 52% female) free of clinically apparent cardiovascular disease.INTERVENTIONS:
Physical activity induces beneficial physiological cardiac remodelling in a cross-sectional study of non-athlete individuals. MAIN OUTCOMEMEASURES:
Left ventricular mass, volumes and function were assessed by cardiac magnetic resonance imaging. Physical activity, defined as intentional exercise and total moderate and vigorous physical activity, was assessed by a standard semiquantitative questionnaire.RESULTS:
Left ventricular mass and end-diastolic volume were positively associated with physical activity (eg, 1.4 g/m(2) (women) and 3.1 g/m(2) (men) greater left ventricular mass in the highest category of intentional exercise compared with individuals reporting no intentional exercise; p = 0.05 and p<0.001, respectively). Relationships were non-linear, with stronger positive associations at lower levels of physical activity (test for non-linearity; p = 0.02 and p = 0.03, respectively). Cardiac output and ejection fraction were unchanged with increased physical activity levels. Resting heart rate was lower in women and men with higher physical activity levels (eg, -2.6 beats/minute lower resting heart rate in the highest category of intentional exercise compared with individuals reporting no intentional exercise; p<0.001).CONCLUSIONS:
In a community-based population free of clinically apparent cardiovascular disease, higher physical activity levels were associated with proportionally greater left ventricular mass and end-diastolic volume and lower resting heart rate.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exercise
/
Ventricular Function, Left
/
Ventricular Remodeling
/
Heart Ventricles
Type of study:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Heart
Journal subject:
CARDIOLOGIA
Year:
2010
Document type:
Article
Affiliation country:
Estados Unidos