Levamisole and 5-fluorouracil therapy for resected colon cancer: a new indication.
CMAJ
; 144(3): 297-301, 1991 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-1989708
ABSTRACT
OBJECTIVE:
To evaluate the benefits and risks of postoperative treatment with levamisole plus 5-fluorouracil (5-FU) in patients with colon cancer.DESIGN:
Computerized searches of MEDLINE and CANCERLIT were performed, and the reference list of each retrieved article was checked. Only randomized trials of therapy with levamisole alone or combined with 5-FU for colon cancer without distant metastases were included. The studies were then evaluated with the use of four criteria.RESULTS:
We reviewed six randomized trials, of which three satisfied our criteria. Two studies demonstrated a significant improvement in the survival rate with levamisole plus 5-FU among patients with colon cancer and pathologically confirmed metastases to adjacent lymph nodes (Dukes' stage C). A subgroup analysis in another study demonstrated a similar benefit. The toxic effects of the drugs were generally mild. The three other studies showed no difference in survival rates between the treatment groups; however, the samples were too small to detect a clinically or statistically important difference.CONCLUSIONS:
Because many patients with colon cancer will suffer a relapse we recommend that they be offered the opportunity to participate in clinical trials of adjuvant therapy. For those with stage C disease not entering a clinical trial levamisole plus 5-FU is appropriate adjuvant therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Levamisole
/
Colonic Neoplasms
/
Fluorouracil
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
CMAJ
Journal subject:
MEDICINA
Year:
1991
Document type:
Article