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SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53.
Demma, Mark; Maxwell, Eugene; Ramos, Robert; Liang, Lianzhu; Li, Cheng; Hesk, David; Rossman, Randall; Mallams, Alan; Doll, Ronald; Liu, Ming; Seidel-Dugan, Cynthia; Bishop, W Robert; Dasmahapatra, Bimalendu.
Affiliation
  • Demma M; Department of Tumor Biology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA. Mark.Demma@spcorp.com
J Biol Chem ; 285(14): 10198-212, 2010 Apr 02.
Article in En | MEDLINE | ID: mdl-20124408
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Quinazolines / DNA / Tumor Suppressor Protein p53 / Cell Proliferation / Proto-Oncogene Proteins c-mdm2 / Ubiquitination / Mutation Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Biol Chem Year: 2010 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Quinazolines / DNA / Tumor Suppressor Protein p53 / Cell Proliferation / Proto-Oncogene Proteins c-mdm2 / Ubiquitination / Mutation Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Biol Chem Year: 2010 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos