Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid.
Acta Paediatr
; 99(5): 705-710, 2010 May.
Article
in En
| MEDLINE
| ID: mdl-20146723
ABSTRACT
AIM:
Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens.METHODS:
Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements.RESULTS:
Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p < 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations (<6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004).CONCLUSION:
Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridoxal Phosphate
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Tuberculosis
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AIDS-Related Opportunistic Infections
/
Isoniazid
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Antitubercular Agents
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
Country/Region as subject:
Africa
Language:
En
Journal:
Acta Paediatr
Year:
2010
Document type:
Article