Expression of endothelin-1 and endothelin receptor a in canine ovarian tumours.
Reprod Domest Anim
; 45(6): e465-8, 2010 Dec.
Article
in En
| MEDLINE
| ID: mdl-20210880
ABSTRACT
Ovarian tumours have a low incidence in bitch. Endothelin (ET-1) and endothelin A receptor (ET-A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET-1 and ET-A expression. Seventeen out of twenty tumours were ET-1 positive. Eight out of twenty tumours were ET-A immunohistochemically positive. At molecular level both proteins were proven to be expressed in normal as well as in tumour samples. Our results show that ET-1 and ET-A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Gene Expression Regulation, Neoplastic
/
Endothelin-1
/
Receptor, Endothelin A
/
Dog Diseases
Limits:
Animals
Language:
En
Journal:
Reprod Domest Anim
Journal subject:
MEDICINA REPRODUTIVA
/
MEDICINA VETERINARIA
Year:
2010
Document type:
Article
Affiliation country:
Italia