Biochemical markers of possible immunodepression in military training in harsh environments.
Mil Med
; 175(3): 158-65, 2010 Mar.
Article
in En
| MEDLINE
| ID: mdl-20358704
ABSTRACT
Prolonged, exhaustive exercise frequently leads to an increased incidence of upper respiratory tract illness (URTI) which is linked to transient immunodepression. We investigated potential biochemical markers of stress and fatigue, and URTI symptoms as a surrogate of immunodepression, in US Marines undergoing intensive winter training at altitude. Selected plasma amino acids and leptin (p[Lep]) were measured as possible markers of fatigue and immunodepression, together with nonesterified fatty acids (p[NEFA]) and total antioxidant capacity (p[TAC]). Changes were observed in plasma free tryptophan (p[FT]), p[Gln], p[Lep], p[NEFA], p[TAC] but not branched chain amino acids (p[BCAA]). p[FT] decreased markedly. Resting p[Gln] decreased overall after one month at altitude. p[Gln] routinely decreases 1-2 hrs after prolonged exercise. Importantly, we observed early morning decreases in p[Gln], suggesting a cumulative effect of prolonged activity, stress, and fatigue. Concomitantly, individuals with highest illness scores had the greatest p[Gln] decrease low p[Gln] may therefore be associated with a diminished stress tolerance.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Tract Diseases
/
Biomarkers
/
Exercise Tolerance
/
Environmental Exposure
/
Immune System
/
Immune Tolerance
/
Military Personnel
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Mil Med
Year:
2010
Document type:
Article
Affiliation country:
Reino Unido