[Phospholipid content of plasma membranes and phospholipase C activity in epithelial cells of the large intestine in colitis-associated carcinogenesis in rats].
Ukr Biokhim Zh (1999)
; 81(6): 77-84, 2009.
Article
in Uk
| MEDLINE
| ID: mdl-20387661
ABSTRACT
The decrease of major cytoplasmic membrane phospholipids (phosphatidylcholine and phosphatidylethanolamine) content was established in mucosal epithelial cell under colon inflammation pathology--ulcerative colitis. It was shown that aforementioned changes were associated with the increase of phospholipids' hydrolyzing enzyme--phospholipase C activity and intracellular Ca2+ concentration enlargement. Carcinogenesis stimulation under inflammation was accompanied by phospholipase C activity increase when quantity of investigated phospholipids (phosphatidylcholine, phosphatidylinozytol, phosphatidylserine) separately decreased and cytoplasmic Ca2+ value normalization was established.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Type C Phospholipases
/
Phospholipids
/
Colitis, Ulcerative
/
Cell Membrane
/
Colonic Neoplasms
/
Epithelial Cells
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Language:
Uk
Journal:
Ukr Biokhim Zh (1999)
Year:
2009
Document type:
Article