Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination.
Nat Neurosci
; 13(5): 541-550, 2010 May.
Article
in En
| MEDLINE
| ID: mdl-20418875
ABSTRACT
The mechanisms that regulate the developmental potential of adult neural progenitor populations under physiological and pathological conditions remain poorly defined. Glutamic acid decarboxylase 65 (GAD65)- and Doublecortin (Dcx)-expressing cells constitute major progenitor populations in the adult mouse subventricular zone (SVZ). Under normal physiological conditions, SVZ-derived GAD65-positive and Dcx-positive cells expressed the transcription factor Pax6 and migrated along the rostral migratory stream to the olfactory bulb to generate interneurons. After lysolecithin-induced demyelination of corpus callosum, however, these cells altered their molecular and cellular properties and migratory path. Demyelination upregulated chordin in the SVZ, which redirected GAD65-positive and Dcx-positive progenitors from neuronal to glial fates, generating new oligodendrocytes in the corpus callosum. Our findings suggest that the lineage plasticity of SVZ progenitor cells could be a potential therapeutic strategy for diseased or injured brain.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glycoproteins
/
Cell Differentiation
/
Cerebral Ventricles
/
Demyelinating Diseases
/
Cell Lineage
/
Intercellular Signaling Peptides and Proteins
/
Adult Stem Cells
/
Neurons
Limits:
Animals
Language:
En
Journal:
Nat Neurosci
Journal subject:
NEUROLOGIA
Year:
2010
Document type:
Article
Affiliation country:
Estados Unidos