Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.

Yan, Lin; Huo, Pei; Debenham, John S; Madsen-Duggan, Christina B; Lao, Julie; Chen, Richard Z; Xiao, Jing Chen; Shen, Chun-Pyn; Stribling, D Sloan; Shearman, Lauren P; Strack, Alison M; Tsou, Nancy; Ball, Richard G; Wang, Junying; Tong, Xinchun; Bateman, Thomas J; Reddy, Vijay B G; Fong, Tung M; Hale, Jeffrey J

Yan, Lin; Huo, Pei; Debenham, John S; Madsen-Duggan, Christina B; Lao, Julie; Chen, Richard Z; Xiao, Jing Chen; Shen, Chun-Pyn; Stribling, D Sloan; Shearman, Lauren P; Strack, Alison M; Tsou, Nancy; Ball, Richard G; Wang, Junying; Tong, Xinchun; Bateman, Thomas J; Reddy, Vijay B G; Fong, Tung M; Hale, Jeffrey J.

Affiliation

Yan L; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA. lin_yan@merck.com

J Med Chem ; 53(10): 4028-37, 2010 May 27.

Article in En | MEDLINE | ID: mdl-20423086

Subject(s)

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrans / Pyridines / Anti-Obesity Agents / Receptor, Cannabinoid, CB1 Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: Estados Unidos

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google