Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.

Fray, M Jonathan; Fish, Paul V; Allan, Gillian A; Bish, Gerwyn; Clarke, Nick; Eccles, Rachel; Harrison, Anthony C; Le Net, Jean-Loic; Phillips, Stephen C; Regan, Nicola; Sobry, Cecile; Stobie, Alan; Wakenhut, Florian; Westbrook, Dominique; Westbrook, Simon L; Whitlock, Gavin A

Fray, M Jonathan; Fish, Paul V; Allan, Gillian A; Bish, Gerwyn; Clarke, Nick; Eccles, Rachel; Harrison, Anthony C; Le Net, Jean-Loic; Phillips, Stephen C; Regan, Nicola; Sobry, Cecile; Stobie, Alan; Wakenhut, Florian; Westbrook, Dominique; Westbrook, Simon L; Whitlock, Gavin A.

Affiliation

Fray MJ; Discovery Chemistry, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent, UK.

Bioorg Med Chem Lett ; 20(12): 3788-92, 2010 Jun 15.

Article in En | MEDLINE | ID: mdl-20471260

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Urinary Incontinence, Stress / Norepinephrine / Selective Serotonin Reuptake Inhibitors / Adrenergic Uptake Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: Reino Unido

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