Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function.
BMC Biochem
; 11: 26, 2010 Jul 09.
Article
in En
| MEDLINE
| ID: mdl-20618965
ABSTRACT
BACKGROUND:
SIN3 is a transcriptional repressor protein known to regulate many genes, including a number of those that encode mitochondrial components.RESULTS:
By monitoring RNA levels, we find that loss of SIN3 in Drosophila cultured cells results in up-regulation of not only nuclear encoded mitochondrial genes, but also those encoded by the mitochondrial genome. The up-regulation of gene expression is accompanied by a perturbation in ATP levels in SIN3-deficient cells, suggesting that the changes in mitochondrial gene expression result in altered mitochondrial activity. In support of the hypothesis that SIN3 is necessary for normal mitochondrial function, yeast sin3 null mutants exhibit very poor growth on non-fermentable carbon sources and show lower levels of ATP and reduced respiration rates.CONCLUSIONS:
The findings that both yeast and Drosophila SIN3 affect mitochondrial activity suggest an evolutionarily conserved role for SIN3 in the control of cellular energy production.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drosophila Proteins
/
Sin3 Histone Deacetylase and Corepressor Complex
/
Mitochondria
Limits:
Animals
Language:
En
Journal:
BMC Biochem
Journal subject:
BIOQUIMICA
Year:
2010
Document type:
Article
Affiliation country:
Estados Unidos