Successful tandem (autologous-cord blood) SCT in advanced neuroblastomas with highly amplified MYCN.
Bone Marrow Transplant
; 46(6): 835-9, 2011 Jun.
Article
in En
| MEDLINE
| ID: mdl-20697365
ABSTRACT
Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in three consecutive advanced neuroblastoma cases with marked BM infiltration and high MYCN amplification. Severe acute complications did not occur in any patient and they have maintained disease-free survival for 37-60 months. This strategy appears to be feasible and effective for the treatment of extremely high-risk neuroblastoma cases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nuclear Proteins
/
Oncogene Proteins
/
Cord Blood Stem Cell Transplantation
/
Peripheral Blood Stem Cell Transplantation
/
Neuroblastoma
Type of study:
Prognostic_studies
Limits:
Humans
/
Infant
/
Male
Language:
En
Journal:
Bone Marrow Transplant
Journal subject:
TRANSPLANTE
Year:
2011
Document type:
Article
Affiliation country:
Japón