Photocleavable polyethylene glycol for the light-regulation of protein function.
Bioconjug Chem
; 21(8): 1404-7, 2010 Aug 18.
Article
in En
| MEDLINE
| ID: mdl-20715846
ABSTRACT
PEGylation is commonly employed to enhance the pharmacokinetic properties of proteins, but it can interfere with natural protein function. Protein activity can thus be abrogated through PEGylation, and a controllable means to remove the polyethylene glycol (PEG) group from the protein is desirable. As such, light affords a unique control over biomolecules through the application of photosensitive groups. Herein, we report the synthesis of a photocleavable PEG reagent (PhotoPEG) and its application to the light-regulation of enzyme activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyethylene Glycols
/
Ultraviolet Rays
/
Muramidase
Language:
En
Journal:
Bioconjug Chem
Journal subject:
BIOQUIMICA
Year:
2010
Document type:
Article
Affiliation country:
Estados Unidos