Impaired oxidative metabolism of salicylate in Reye's syndrome.
Dev Pharmacol Ther
; 15(2): 57-60, 1990.
Article
in En
| MEDLINE
| ID: mdl-2078973
ABSTRACT
Administration of salicylates during prodromal viral illness has been associated with the development of Reye's syndrome (RS). We studied salicylate biotransformation in RS patients and compared it with those on chronic salicylate therapy for juvenile rheumatoid arthritis (JRA). Urine of RS patients contained significantly more salicylic acid and less gentisic acid than that of JRA patients while the conjugated metabolites were not different between the two groups. These results suggest decreased salicylate microsomal oxidation in RS. The role of altered salicylate metabolism in the pathogenesis of RS is unclear.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Juvenile
/
Reye Syndrome
/
Salicylates
/
Gentisates
Limits:
Humans
Language:
En
Journal:
Dev Pharmacol Ther
Year:
1990
Document type:
Article