Gender differences in bone mineral density in obese children during pubertal development.
J Endocrinol Invest
; 34(4): e86-91, 2011 Apr.
Article
in En
| MEDLINE
| ID: mdl-20855933
ABSTRACT
OBJECTIVE:
To investigate whether body mass index (BMI) and body composition can affect peak bone mass in a population of obese (OB) (BMI SDS>2.0) and normal weight (NORM) (BMI-SD score <2.0) pubertal subjects (Tanner stage T3 to T5). PATIENTS ANDMETHODS:
151 subjects (81 OB, age 14.5±2.4 yr) were analyzed using dual-X-ray absorbiometry technique to study Lumbar and whole body bone mineral density (BMD) (areal, normalized for height) and Z-score, lean mass (LM) and lean/fat ratio.RESULTS:
As a whole group, OB males did not show any significant difference in bone parameters vs NORM, while OB females showed higher bone density parameters (p<0.05). When grouped according to T, while OB males showed higher bone density at T3-4 stage (p<0.01), and lower at T5 (p<0.01) compared to NORM, OB females showed a tendency through increased BMD at T3-4 and T5 although statistically different only at T5. BMD was independently correlated to LM, lean/fat ratio, and testosterone in NORM males and, at lower level, in OB males, while to LM in NORM females and only to age in OB females.CONCLUSION:
Our data seem to confirm the possible negative influence of obesity on bone density in boys, a possible explanation could be an unfavorable body composition during sexual maturation that seems not to affect bone development in adolescents girls.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Body Composition
/
Body Mass Index
/
Bone Density
/
Puberty
/
Sex Characteristics
/
Obesity
Aspects:
Determinantes_sociais_saude
Limits:
Adolescent
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Endocrinol Invest
Year:
2011
Document type:
Article
Affiliation country:
Italia