Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish.
Behav Brain Res
; 217(1): 10-5, 2011 Feb 02.
Article
in En
| MEDLINE
| ID: mdl-20888863
ABSTRACT
Demographic aging gives rise to a growing population with age-associated behavioral and cognitive deficits that may be associated at least partially to the increasing prevalence of neurodegenerative disorders, such as Alzheimer's disease (AD). In this disease, it has been observed a decrease in the cholinergic system, which is crucial to memory formation. Scopolamine-induced amnesic effect, through the disruption of the cholinergic neurotransmission, is one of the approaches used to investigate the mechanisms involved in cognitive impairment observed in AD. The aim of our study was to investigate the potential protective role of quercetin and rutin against scopolamine-induced inhibitory avoidance memory deficits in zebrafish. Scopolamine (200 µM dissolved in the tank water for 1h) given pre-training hindered memory formation while both quercetin and rutin pretreatments (50mg/kg, single injection, i.p.) prevented the scopolamine-induced amnesia. None of the compounds affected zebrafish general locomotor activity. Together, these results contribute to the increase of the knowledge about plant compounds applicability as medicines to prevent and treat neurodegenerative diseases, like Alzheimer's disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quercetin
/
Rutin
/
Scopolamine
/
Memory Disorders
/
Antioxidants
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Behav Brain Res
Year:
2011
Document type:
Article
Affiliation country:
Brasil