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Pharmacokinetics of polymyxin B in an infant with multidrug-resistant Klebsiella pneumoniae bacteremia.
Salvatore, Christine M; Abdelraouf, Kamilia; Hsing, Deyin D; Tam, Vincent H.
Affiliation
  • Salvatore CM; Division of Pediatric Infectious Diseases, Weill-Cornell Medical College, New York, NY, USA. chs2032@med.cornell.edu
Pediatr Infect Dis J ; 30(6): 537-9, 2011 Jun.
Article in En | MEDLINE | ID: mdl-21164382
ABSTRACT
We report our experience with a 9-month-old infant treated with intravenous polymyxin B for multidrug-resistant Klebsiella pneumoniae bacteremia. Serial blood samples were obtained at steady state and serum drug concentrations were determined using a validated liquid chromatography-mass spectrometry method. The elimination half-lives of polymyxin B1 and isoleucine-polymyxin B1 were found to be 3.1 and 4.7 hours, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymyxin B / Klebsiella Infections / Bacteremia / Drug Resistance, Multiple, Bacterial / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Female / Humans / Infant Language: En Journal: Pediatr Infect Dis J Journal subject: DOENCAS TRANSMISSIVEIS / PEDIATRIA Year: 2011 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymyxin B / Klebsiella Infections / Bacteremia / Drug Resistance, Multiple, Bacterial / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Female / Humans / Infant Language: En Journal: Pediatr Infect Dis J Journal subject: DOENCAS TRANSMISSIVEIS / PEDIATRIA Year: 2011 Document type: Article Affiliation country: Estados Unidos