IgG responses to tissue-associated antigens as biomarkers of immunological treatment efficacy.
J Biomed Biotechnol
; 2011: 454861, 2011.
Article
in En
| MEDLINE
| ID: mdl-21197272
ABSTRACT
We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy (n = 34), a poxviral vaccine (n = 31), and a DNA vaccine (n = 21). Changes in IgG responses to individual antigens were identified by phage immunoblot. Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network (ML-BBN). We found that different antigens were recognized following androgen deprivation compared with vaccine therapies. While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Immunoglobulin G
/
Biomarkers, Tumor
/
Antigens, Neoplasm
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
Language:
En
Journal:
J Biomed Biotechnol
Journal subject:
BIOTECNOLOGIA
/
MEDICINA
Year:
2011
Document type:
Article
Affiliation country:
Estados Unidos