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[Long-term follow-up of isolated-growth hormone deficiency typeIA: the clinical analysis of 2-sister cases].
Chang, Guo-ying; Dong, Zhi-ya; Wang, Wei; Wang, De-fen.
Affiliation
  • Chang GY; Department of Pediatrics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhonghua Er Ke Za Zhi ; 48(12): 944-6, 2010 Dec.
Article in Zh | MEDLINE | ID: mdl-21215191
OBJECTIVE: To elucidate the curative and adverse effect of recombinant human growth hormone (rhGH) in 2 patients with isolated-growth hormone deficiency type IA (IGHDIA), to track sexual development and pregnancy, and reassess the quality of life in the adulthood. METHOD: The authors summarized the data of 2-sister cases with IGHDIA; followed up for assessment of height, weight, blood pressure and sexual development; detected fasting blood lipids, glucose, insulin, insulin growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3); made an investigation of education and occupation, and so on. RESULT: After 6.2 and 7.3 years treatment with rhGH, the two sisters had considerably improved height from -7.8 SDS, -8.8 SDS to -2.6 SDS and -1.3 SDS respectively. No evident side effect was observed. They had normal sexual development and pregnancy. The levels of IGF-1 and IGFBP-3 were still low, in the elder sister they were 46.6 µg/L, 2460 µg/L, and in the younger 52.4 µg/L, 2430 µg/L. No hyperlipidemia, diabetes or obesity occurred. CONCLUSION: Long term therapy with rhGH may improve final adult height of individuals with IGHDIA. They can have normal sexual development and pregnancy. Metabolic syndrome did not occur during the follow-up period.
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Collection: 01-internacional Database: MEDLINE Main subject: Dwarfism, Pituitary Type of study: Observational_studies / Prognostic_studies Aspects: Patient_preference Limits: Child / Female / Humans Language: Zh Journal: Zhonghua Er Ke Za Zhi Year: 2010 Document type: Article Affiliation country: China Country of publication: China
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Collection: 01-internacional Database: MEDLINE Main subject: Dwarfism, Pituitary Type of study: Observational_studies / Prognostic_studies Aspects: Patient_preference Limits: Child / Female / Humans Language: Zh Journal: Zhonghua Er Ke Za Zhi Year: 2010 Document type: Article Affiliation country: China Country of publication: China