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HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Rolny, Charlotte; Mazzone, Massimiliano; Tugues, Sònia; Laoui, Damya; Johansson, Irja; Coulon, Cathy; Squadrito, Mario Leonardo; Segura, Inmaculada; Li, Xiujuan; Knevels, Ellen; Costa, Sandra; Vinckier, Stefan; Dresselaer, Tom; Åkerud, Peter; De Mol, Maria; Salomäki, Henriikka; Phillipson, Mia; Wyns, Sabine; Larsson, Erik; Buysschaert, Ian; Botling, Johan; Himmelreich, Uwe; Van Ginderachter, Jo A; De Palma, Michele; Dewerchin, Mieke; Claesson-Welsh, Lena; Carmeliet, Peter.
Affiliation
  • Rolny C; Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, 75185 Uppsala, Sweden.
Cancer Cell ; 19(1): 31-44, 2011 Jan 18.
Article in En | MEDLINE | ID: mdl-21215706
Subject(s)
Down-Regulation/genetics; Macrophages/immunology; Neoplasms/immunology; Neoplasms/pathology; Neovascularization, Pathologic/immunology; Pregnancy Proteins/metabolism; Proteins/metabolism; Animals; Antibodies/immunology; Antibodies/pharmacology; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Chemotactic Factors/metabolism; Clodronic Acid/pharmacology; Culture Media, Conditioned/pharmacology; Cytokines/metabolism; Dendritic Cells/immunology; Dendritic Cells/metabolism; Dendritic Cells/pathology; Endothelial Cells/cytology; Endothelial Cells/drug effects; Gene Expression/drug effects; Gene Expression/genetics; Humans; Hypoxia/genetics; Hypoxia/metabolism; Lung Neoplasms/genetics; Lung Neoplasms/immunology; Lung Neoplasms/pathology; Lung Neoplasms/secondary; Macrophages/drug effects; Macrophages/metabolism; Macrophages/pathology; Macrophages, Peritoneal/drug effects; Macrophages, Peritoneal/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Microvessels/drug effects; Microvessels/pathology; Microvessels/ultrastructure; Neoplasm Metastasis/genetics; Neoplasm Metastasis/immunology; Neoplasm Metastasis/pathology; Neoplasms/blood supply; Neoplasms/genetics; Neoplasms/metabolism; Neovascularization, Pathologic/genetics; Neovascularization, Pathologic/pathology; Placenta Growth Factor; Pregnancy Proteins/genetics; Pregnancy Proteins/immunology; Proteins/genetics; Proteins/pharmacology
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Proteins / Proteins / Down-Regulation / Macrophages / Neoplasms / Neovascularization, Pathologic Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: Suecia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Proteins / Proteins / Down-Regulation / Macrophages / Neoplasms / Neovascularization, Pathologic Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: Suecia