Oral vaccination of Atlantic salmon (Salmo salar) against salmonid rickettsial septicaemia.
Vaccine
; 29(12): 2336-40, 2011 Mar 09.
Article
in En
| MEDLINE
| ID: mdl-21219985
ABSTRACT
Effective oral immunization systems may be very helpful to the salmon industry, particularly during the seawater growth stages in which vaccination through injection is not possible. During the seawater growing stage, fish become more susceptible to several types of disease, due to the natural decay of vaccine-induced immune responses. In this study, we demonstrate the immune response and efficacy of a new salmonid rickettsial septicaemia (SRS) oral vaccine, developed using MicroMatrix™ Technology. The vaccine, which is administered together with daily feed ration, induces a specific immune response at local and systemic levels. Anti-Piscirickettsia salmonis specific antibodies were detected as soon as 300 degree-days after vaccination. Furthermore, oral vaccination was able to protect fish against a lethal pathogen challenge when administered either as a primary vaccination or as a booster for an injected vaccine. Results show that oral vaccination is an efficacious treatment for the prevention of SRS outbreaks throughout the salmon culture period.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Vaccines
/
Salmo salar
/
Piscirickettsiaceae Infections
/
Fish Diseases
Limits:
Animals
Language:
En
Journal:
Vaccine
Year:
2011
Document type:
Article
Affiliation country:
Chile