Accuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation.
Clin Radiol
; 66(4): 349-56, 2011 Apr.
Article
in En
| MEDLINE
| ID: mdl-21295772
ABSTRACT
AIM:
To evaluate the diagnostic accuracy of multidetector computed tomography (MDCT) for hepatocellular carcinoma (HCC) in cirrhotic patients undergoing liver transplantation. Secondary aims were to examine the effect of radiologist experience and lesion size on diagnostic accuracy. MATERIALS ANDMETHODS:
Thirty-nine patients (72% male with a mean age of 56.5 years) underwent liver transplantation following preoperative triple-phase MDCT examination of the liver. MDCT examinations were retrospectively independently reviewed by three radiologists for the presence and location of suspected HCCs, with the diagnostic confidence recorded using a five-point confidence scale. MDCT examinations were compared with explant specimens for histopathological correlation.RESULTS:
Histopathological results demonstrated 46 HCCs in 29 of the 39 patients. Analysis demonstrated a sensitivity of 65-75% and specificity of 47-88% for detection of HCC lesions. The sensitivity dropped to 48-57% for lesions of size ≤20mm. As the diagnostic confidence increased, there was a further decrease in the sensitivity (4-26%). The radiologist with the greatest number of years experience was found to have a significantly higher accuracy of detection of HCC lesions compared with the least experienced radiologist.CONCLUSION:
Larger lesion size of HCC and greater number of years experience of the radiologist resulted in significantly higher accuracy of HCC lesion detection. The overall sensitivity and specificity results for MDCT detection of HCC are comparable to previous helical CT imaging.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tomography, X-Ray Computed
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Liver Transplantation
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Carcinoma, Hepatocellular
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Liver Neoplasms
Type of study:
Diagnostic_studies
/
Evaluation_studies
Limits:
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Clin Radiol
Year:
2011
Document type:
Article
Affiliation country:
Reino Unido