p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.
Oncogene
; 30(18): 2087-97, 2011 May 05.
Article
in En
| MEDLINE
| ID: mdl-21297668
ABSTRACT
p16(Ink4a) is a protein involved in regulation of the cell cycle. Currently, p16(Ink4a) is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16(Ink4a) has also been described in several tumors. This review attempts to elucidate when and why p16(Ink4a) overexpression occurs, and to suggest possible implications of p16(Ink4a) in the diagnosis, prognosis and treatment of cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Genes, Tumor Suppressor
/
Cyclin-Dependent Kinase Inhibitor p16
/
Neoplasms
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Oncogene
Journal subject:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Year:
2011
Document type:
Article
Affiliation country:
España