Large volume leukapheresis: Efficacy and safety of processing patient's total blood volume six times.
Transfus Apher Sci
; 44(2): 139-47, 2011 Apr.
Article
in En
| MEDLINE
| ID: mdl-21320801
ABSTRACT
Large-volume leukapheresis (LVL) differs from standard leukapheresis by increased blood flow and an altered anticoagulation regimen. An open issue is to what degree a further increase in processed blood volume is reasonable in terms of higher yields and safety. In 30 LVL performed in patients with hematologic malignancies, 6 total blood volumes were processed. LVL resulted in a higher CD34+ cell yield without a change in graft quality. Although a marked platelet decrease can be expected, LVL is safe and can be recommended as the standard procedure for patients who mobilize low numbers of CD34+ cells and when high number of CD34+ cells are required.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukapheresis
/
Hematologic Neoplasms
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Transfus Apher Sci
Journal subject:
HEMATOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Croacia