Investigation into the presence of and serological response to XMRV in CFS patients.
PLoS One
; 6(3): e17592, 2011 Mar 09.
Article
in En
| MEDLINE
| ID: mdl-21408077
ABSTRACT
The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fatigue Syndrome, Chronic
/
Xenotropic murine leukemia virus-related virus
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
PLoS One
Journal subject:
CIENCIA
/
MEDICINA
Year:
2011
Document type:
Article
Affiliation country:
Reino Unido